Effects on endocrine metabolism were observed in patients with schizophrenia receiving paliperidone palmitate
陆敏 1班春霞 1李冠军 2高存友 1李广伟 1程诚 1李莉 1周耀明 1陈敬兰 1孙仲礼1
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作者信息
1. 201806 上海市嘉定区精神卫生中心
2. 上海市精神卫生中心
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摘要
目的:评估精神分裂症患者接受棕榈酸帕利哌酮注射液1个月剂型(once-monthly paliperidone palmitate,PP1M)治疗后内分泌、代谢情况.方法:对51例口服利培酮治疗有效的精神分裂症患者换用PP1M治疗后,于基线及治疗后1个月、3个月、6个月、12个月监测内分泌、代谢等相关指标,于基线及治疗后12个月对患者进行个体和社会功能量表(personal and social performance scale,PSP)评估.结果:治疗12个月时PSP因子分对社会有益的活动、扰乱及攻击行为两项与基线相比,差异具有统计学意义(t=-2.07、3.71,P均＜0.05);重复测量方差分析显示,不同时间点,患者体质量指数、腰围、血糖、血脂等指标差异均无统计学意义(P＞0.05);而在血清泌乳素(prolactin,PRL)上,差异具有统计学意义(F=3.021,P＜0.05),且各个时间点血清泌乳素浓度均高于基线(P均＜0.05).结论:PP1M对代谢影响较小,且能改善患者社会功能,但会导致血清PRL水平增高,需引起关注.
Abstract
Objective:To evaluate the endocrine and metabolic conditions of patients with schizophrenia after treatment with once-monthly paliperidone palmitate(PP1M).Method:51 patients with schizophrenia who responded well to oral risperidone treatment were monitored for endocrine and metabolic related indicators at baseline and 1 month,3 months,6 months,and 12 months after switching to PP1M treatment for 1 year.The personal and social performance scale(PSP)was used to evaluate the individual and social function of the patients at baseline and 12 months after treatment.Results:After one year of PP1M treatment,there were significant differences in the PSP factor scores of beneficial activities to society and disruption and aggressive behavior compared to the baseline values(t=-2.07、3.71,all P＜0.05).Repeated measures variance analysis showed that there were no significant differences in body mass index,waist circumference,blood sugar,and blood lipid levels at different time points(all P＞0.05).However,there were significant differences in serum prolactin(PRL)concentration(F=3.021,all P＜0.05),with serum PRL levels at each time point being higher than the baseline levels,and the differences were all significant(all P＜0.05).Conclusion:Long-term use of PP1M for the treatment of schizophrenia has no significant impact on metabolism,but it can cause a significant increase in prolactin levels,and this needs attention.
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