目的:对已求助的精神病临床高危(clinical-high-risk for psychosis,CHR)个体进行随访,明确转化风险.方法:对2015年至2019年在北京安定医院就诊,符合精神病风险综合征定式访谈(structured interview for psychosis risk syndromes,SIPS)的 70 例 CHR 个体,于 2017 年、2019 年及 2022 年进行3次随访.经SIPS评估判定是否转化,《国际疾病分类》第10版明确诊断.结果:60例CHR个体接受随访,平均随访时间41.82个月(范围3～86个月).其中23例转化,37例未转化,中位转化时间14.00个月(范围3～34个月).生存分析1年转化率25％,2年转化率30％,3年转化率36％.结论:CHR转化集中在前3年,约36％转化为精神分裂症、双相障碍等精神障碍.
Conversion study of individuals at clinical-high-risk for psychosis
Objective:To identify conversion risk by following up individuals with clinical-high-risk for psychosis(CHR).Method:70 CHR individuals through the structured interview for psychosis risk syndromes(SIPS)screening were included in Beijing Anding Hospital from 2015 to 2019.3 follow-ups were conducted in 2017,2019 and 2022.SIPS and the 10th edition of the international classification of diseases were used to determine conversion and diagnosis respectively.Results:60 CHR individuals were followed for a mean time of 41.82 months(range 3-86 months).Among them,23 cases were converted,37 cases were unconverted,and the median conversion time was 14.00 months(range 3-34 months).Survival analysis showed a conversion rate of 25％at 1 year,30％at 2 years,and 36％at 3 years.Conclusion:The conversion from CHR to psychosis is concentrated in the first 3 years of onset,and about 36％of individuals are converted to mental disorders such as schizophrenia and bipolar disorder.
clinical-high-risk for psychosisfollow-upconversion
万方数据
维普
