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青少年首发抑郁障碍患者自杀未遂影响因素分析

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目的:探讨青少年首发抑郁障碍患者自杀未遂的影响因素.方法:纳入2020年7月至2022年2月河北省精神卫生中心青少年首次抑郁障碍住院患者125例,根据有无自杀未遂分为伴自杀未遂组(51例)和不伴自杀未遂组(74例),比较两组患者人口学特征、疾病特征及相关指标.结果:伴自杀未遂组17项汉密尔顿抑郁量表(Hamilton depression rating scale-17,HAMD-17)中有罪感因子分、工作和兴趣因子分以及总分均高于不伴自杀未遂组;血同型半胱氨酸水平、甲状腺功能中游离甲状腺素(free thyroxine 4,FT4)均低于不伴自杀未遂组(P 均<0.05).HAMD-17 总分(OR=1.194)、FT4(OR=0.051)与青少年首发抑郁障碍患者的自杀未遂相关联.结论:青少年首发抑郁障碍患者抑郁症状越严重,自杀未遂发生率越高;血清FT4水平与自杀未遂行为的发生呈负相关.
Analysis of influencing factors of suicide attempt in adolescents with first-episode depressive disorder
Objective:To investigate the influencing factors of suicide attempt in adolescents with first-episode depressive disorder.Method:From July 2020 to February 2022,a total of 125 adolescents with first-episode depressive disorder in Hebei Provincial Mental Health Center were recruited,they were divided into a group with attempted suicide(51 cases)and a group without attempted suicide(74 cases).The demographic characteristics,disease characteristics and related indicators were compared between the two groups.Results:The scores of guilt factor,work and interest factor and total score of Hamilton depression rating scale-17(HAMD-17)in the attempted suicide group were higher than those in the non-attempted suicide group.The serum homocysteine level,free thyroxine 4(FT4)in thyroid function in the attempted suicide group were lower than those in the non-attempted suicide group(all P<0.05).The total score of HAMD-17(OR=1.194)and FT4(OR=0.051)were associated with suicidal behavior in adolescents with first-episode depressive disorder.Conclusion:The more severe the depressive symptoms of adolescent patients with first-episode depressive disorder,the higher the incidence of attempted suicide.The level of serum FT4 was negatively correlated with the occurrence of attempted suicide.

adolescentfirst episode depressionattempted suicideinfluencing factors

芦云平、周梦迪、于超、宋丽华、张丽丽、崔伟

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071000 河北省精神卫生中心,河北省重大精神与行为障碍疾病研究重点实验室,河北大学第六临床医学院

青少年 首发抑郁障碍 自杀未遂 影响因素

2024

临床精神医学杂志
南京医科大学附属脑科医院

临床精神医学杂志

CSTPCD
影响因子:1.108
ISSN:1005-3220
年,卷(期):2024.34(6)