A study of near-infrared brain function characteristics in patients with first-episode depression with suicidal ideation
Objective:To investigate prefrontal cortical activity based on functional near-infrared spectroscopy(fNIRS)in patients with first-episode untreated depression with suicidal ideation,and to explore the brain activation characteristics of the patients and their correlation with suicidal ideation.Method:Ninety-three patients with first-episode untreated depression were included and categorised into the suicidal ideation group(n=45)and the no suicidal ideation group(n=48)based on the presence or absence of≥1 suicidal items on the 17-item Hamilton Depression Scale,with the concurrently recruited healthy control group(n=42),and prefrontal cortical activity was assessed by fNIRS during performance of a verbal fluency task.Results:Depressed patients had reduced activation in the prefrontal cortex compared to the healthy control group.Post hoc analyses showed that the suicidal ideation group had less activation in the right orbitofrontal cortex than the no suicidal ideation and the healthy control group.Activation in the ventral lateral prefrontal cortex,frontal pole cortex,and orbitofrontal cortex in the suicidal ideation group was negatively correlated with suicide scores,with the largest correlation located in the orbitofrontal cortex.Conclusion:The suicidal ideation group had a different pattern of fNIRS signalling changes in the right orbitofrontal cortex,which may help in the early identification of suicidal ideation.
万方数据
维普
