酒精使用障碍(alcohol use disorder,AUD)是一种遗传和环境因素共同作用的神经精神障碍,长期慢性摄入酒精会引起大脑基因表达网络的永久性改变.非编码RNA(non-protein-coding RNA,ncRNA)被认为是与神经精神障碍中调控基因表达有关的一类RNA,这类RNA分子通过特异性地调控靶基因的转录后翻译过程、神经元突触间的一系列反应等在AUD机制中发挥重要作用,在人体酒精代谢过程中,ncRNA参与调节酶和神经递质反应系统.饮酒可以调节ncRNA的表达,介导表观遗传修饰和神经元突触可塑性,它们被认为是基因表达的重要调节因子.更深入地了解ncRNA在AUD机制中的作用可能为针对性治疗提供新的思路.
Research progress of non-coding RNA in alcohol use disorder gene regulation
Alcohol use disorder(AUD)is a neuropsychiatric disorder characterized by a combination of genetic and environmental factors.Long-term and chronic consumption of alcohol causes permanent changes in gene expression networks in the brain.Non-protein-coding RNA(ncRNA)is considered to be a class of RNA involved in regulating gene expression in neuropsychiatric diseases.Such RNA molecules play an important role in AUD mechanism by specifically regulating the post-transcriptional translation process of target genes and a series of synaptic responses.ncRNA are involved in enzyme and neurotransmitter reaction systems during alcohol metabolism.Alcohol consumption regulates the expression of ncRNA,mediates epigenetic modifications and synaptic plasticity,which are considered to be important regulators of gene expression.A deeper understanding of the role of ncRNA in AUD may provide new ideas for targeted therapy.
non-protein-coding RNAsynaptic plasticityepigeneticalcohol use disorder
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