Correlation between MASP family expression levels and risk of poor prognosis in patients with sepsis
Objective:To analyze the correlation between the expression level of mannan-binding lectin associ-ated serine proteases(MASP)family and the risk of poor prognosis of patients with sepsis.Methods:One hundred and thirteen patients with sepsis diagnosed and treated in the First Affiliated Hospital of Hainan Medical College from January 2018 to December 2022 were included in the study.All patients were given standardized treatment such as fluid infusion and anti-infection after admission.According to whether the patients died within 28 days,they were divided into death group and survival group.Comparing the general clinical data and laboratory indexes such as MASP family expression levels of the two groups,and the multivariate logistic regression model was used to analyze the factors affecting the prognosis of the patients and the correlation between the expression level of MASP family and acute physiology and chronic health evaluation(APACHE Ⅱ)score.Results:The level of A-PACHE Ⅱ score,white blood cell,hypersensitive C-reactive protein,MASP-1,MASP-2 and MASP-3 in the death group were significantly higher than that in the survival group(27.17±2.89)scores,(15.34±2.11)×109/L,(26.19±3.87)mg/L,(4 076.48±114.78)ng/L,(58.75±6.31)ng/L,(349.86±61.37)ng/L vs.(25.51± 2.36)scores,(14.23±1.64)×109/L,(28.36±3.92)mg/L,(3 848.65±89.24)ng/L,(48.22±3.54)ng/L,(216.93±54.74)ng/L,all P＜0.05.While the level of albumin in the death group were significantly lower than those in the survival group(20.34±2.34)g/L vs.(24.78±2.61)g/L,P＜0.001.Multivariate logistic regression analysis showed that the high level of MASP-1(OR=1.019,P=0.019,95％CI:1.003-1.036)、MASP-2(OR=1.557,P=0.019,95％CI:1.078-2.306)and MASP-3(OR=1.033,P=0.047,95％CI:1.000-1.066)were independent risk factors which affecting the prognosis of patients.Pearson correlation analysis showed that the levels of MASP-1,MASP-2 and MASP-3 were positively correlated with APACHE Ⅱ score(R=0.792,0.763,0.511,all P＜0.001).Conclusion:The increased expression of MASP family is positively correlated with poor prognosis in patients with sepsis.
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