Effect of mild hypothermia on coagulation function and prognosis after acute moderate to severe craniocerebral injury
Objective:To study the characteristics of coagulation dysfunction in patients with acute moderate to severe traumatic brain injury(TBI)and the effect of mild hypothermia therapy on their prognosis.Methods:This retrospective cohort study included all adult patients with moderate to severe TBI admitted to the Department of Critical Care Medicine of Wujin Hospital Affiliated to Jiangsu University from June 2021 to June 2023(152 cases),and obtained detailed information on patient demographics and trauma characteristics were obtained.According to the 28d prognosis of patients,they were divided into survival group(107 cases)and death group(45 cases).Ac-cording to different treatment methods,they were divided into mild hypothermia group(69 cases)and control group(83 cases).The coagulation function of the mild hypothermia group and the control group at different time points was measured after admission to the intensive care department.Results:The results showed that before treatment prothrombin time,thrombin time,activated partial thromboplastin time were significantly prolonged and D-dimer was significantly increased in the death group,and the differences among all groups were statistically significant(P＜0.05).In the survival group,the blood clotting index fibrinogen in the mild hypothermia group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion:Coag-ulation dysfunction is very common after acute moderate to severe cranial injury,and mild hypothermia may have a certain effect on coagulation function,which is worth further studying.
moderate to severe craniocerebral injurymild hypothermiacoagulation function
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