Clinical study on Shenfu injection in the treatment of septic shock patients
Objective:To explore the effect of Shenfu injection on coagulation function,sublingual microcircu-lation and prognosis of septic shock patients.Methods:One hundred and fifty patients with septic shock were col-lected from the Department of Critical Care Medicine of Shanghai Pudong New Area People's Hospital from Janu-ary 1,2022 to June 30,2023.The age and sex of the patients,the initial blood lactic acid,white blood cell count,platelet count,C-reactive protein,hemoglobin,albumin,coagulation function and sublingual microcirculation pa-rameters on the first and seventh day of admission,and the sequential organ failure assessment score,acute physi-ology and chronic health evaluation Ⅱ score and 90-day survival status were recorded.Patients were randomly di-vided into experimental group(75 cases)and control group(75 cases).The differences of coagulation function,sublingual microcirculation improvement and prognosis between the two groups were compared.Results:After treatment,the indexes of coagulation function in the two groups were better than before,and the difference be-tween the two groups was statistically significant(P＜0.05).The parameters of sublingual microcirculation were improved after treatment,especially in the experimental group,and the difference between the two groups was statistically significant(P＜0.05).Kaplan-Meier survival analysis showed that the 90-day survival rate of patients in the experimental group was higher(experimental group vs.control group:78.7％vs.70.7％),but there was no significant difference between the two groups(P=0.26).Conclusion:Shenfu injection can improve the coagu-lation function and sublingual microcirculation of septic shock patients,and has certain value in improving prog-nosis.
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