脓毒症中T细胞亚群变化诱导的免疫抑制
Immunosuppression induced by changes of T lymphocytes subsets in sepsis
张萌 1杨正飞1
作者信息
- 1. 中山大学孙逸仙纪念医院急诊科(广州,510120)
- 折叠
摘要
脓毒症是由创伤、感染等引起的临床急危重综合征,其患病率和死亡率在全球范围内居高不下.随着对脓毒症病理生理机制研究的深入,免疫调节逐渐成为该领域研究热点,而T淋巴细胞是机体免疫状态的关键特征指标,其功能受损和数量锐减是导致脓毒症患者后期免疫麻痹甚至死亡的重要因素.本文综述了 CD8+、CD4+及调节性T细胞在脓毒症中的变化情况和致病机制,同时分析了各类T细胞抑制性免疫检查点在脓毒症中的分子作用机制,最后阐述了脓毒症免疫治疗的相关研究进展,以期为脓毒症临床监测和治疗提供新的研究靶点和思路.
Abstract
Sepsis is a clinical acute and critical syndrome resulting from trauma,infection,etc.,and its mor-bidity and mortality rates are still high worldwide.Further studies on the pathophysiology of sepsis indicate that immunoregulation is a research hotspot.T lymphocytes are the key indicator of immune status,and the function impairment and depletion of T cells are important cause of immune paralysis and even death for sepsis patients at later stage.In this review,we summarized the changes and pathogenic mechanisms of CD8+,CD4+and regulato-ry T cells in sepsis,we meanwhile analyzed the molecular mechanism of various inhibitory immune checkpoints in sepsis.The relevant research progress of immunotherapy in sepsis was also reviewed.We hope this article can provide new research targets and ideas for clinical monitoring and treatment of sepsis.
关键词
脓毒症/免疫抑制/T淋巴细胞/抑制性免疫检查点/免疫治疗Key words
sepsis/immunosuppression/T lymphocytes/inhibitory immune checkpoint/immunotherapy引用本文复制引用
基金项目
广东省自然科学基金(2021A1515011433)
广州市科技局基础与应用基础研究项目(202201010856)
出版年
2024
NETL
NSTL
万方数据