Immunosuppression induced by changes of T lymphocytes subsets in sepsis
Sepsis is a clinical acute and critical syndrome resulting from trauma,infection,etc.,and its mor-bidity and mortality rates are still high worldwide.Further studies on the pathophysiology of sepsis indicate that immunoregulation is a research hotspot.T lymphocytes are the key indicator of immune status,and the function impairment and depletion of T cells are important cause of immune paralysis and even death for sepsis patients at later stage.In this review,we summarized the changes and pathogenic mechanisms of CD8+,CD4+and regulato-ry T cells in sepsis,we meanwhile analyzed the molecular mechanism of various inhibitory immune checkpoints in sepsis.The relevant research progress of immunotherapy in sepsis was also reviewed.We hope this article can provide new research targets and ideas for clinical monitoring and treatment of sepsis.
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