Evaluation of the clinical efficacy of Ji Desheng snake tablets combined with aminophenol tramadol in patients by pit viper bites in Xuzhou and its surrounding areas
Objective:To observe the clinical effect of Ji Desheng snake tablets combined with aminophenol tramadol in patients by pit viper bites in Xuzhou and its surrounding areas.Methods:The clinical data of 244 pit viper bite patients hospitalized in the emergency ward of Xuzhou Central Hospital from May 2019 to September 2023 were retrospectively analyzed.Patients were divided into the group of Ji Desheng snake tablet combined with aminophenol tramadol(Group A,114 cases)and the group of Ji Desheng snake tablet alone(Group B,130 cases).The main observation was the comparison of hospitalization time and pain subsidence time between the two groups.At the same time,the pain scores,interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),white blood cell count(WBC),percentage change in neutrophil count before treatment,on the first day of treat-ment,and on the third day of treatment,as well as the occurrence rates of adverse events and the need for remedi-al analgesia in both groups were observed.Results:The 244 patients belonged to 80 cases(32.8％)in Xuzhou Cit-y,84 cases(34.4％)in Suzhou City,42 cases(17.2％)in Huaibei City,and 38 cases(15.6％)in Suqian City.There were no significant differences in gender,age,body mass index,underlying disease,bite site,bite severity score,pre-treatment pain score,pre-treatment hs-CRP,pre-treatment IL-6,pre-treatment WBC,and pre-treat-ment neutrophil percentage between the two groups.Pain subsidence time and hospitalization time were signifi-cantly shorter in group A compared with group B,and the difference was statistically significant(P＜0.05).On the first day of treatment,the pain score and IL-6 of group A significantly decreased compared with group B,and the difference was statistically significant(P＜0.05).On the third day of treatment,the pain scores and IL-6 of both group A and group B significantly decreased compared with the pre-treatment period,and there was no sig-nificant difference between the two groups.Compared with group B,the level of hs-CRP,WBC,neutrophil per-centage expression significantly decreased in group A on the first day of treatment,and the difference was statisti-cally significant(P＜0.05).On the third day of treatment,there was no significant difference in the level of hs-CRP,WBC,and neutrophil percentage expression between group A and group B.No adverse events were oc-curred in both groups.There was 2 case(1.8％)of remedial analgesia in group A and 14 cases(10.8％)of reme-dial analgesia in group B,and the difference was statistically significant(P＜0.05).Conclusion:The regimen of Chinese patent medicine Ji Desheng snake tablets combined with western medicine aminophenol tramadol can sig-nificantly alleviate the pain and shorten the hospital stay of patients with pit viper bites.This is beneficial for the rapid recovery of patients and is worthy of further clinical promotion and application.
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