Effect of bilevel positive airway pressure on the level of mid-regional proadrenomedullin in patients with moderate to severe acute exacerbations of chronic obstructive pulmonary disease complicated with type Ⅱ respiratory failure
Objective:To investigate the effect of bilevel positive airway pressure(BiPAP)on the serum mid-regional proadrenomedullin(MR-proADM)level,arterial blood gas analysis of PCO2 level and pulmonary function in patients with moderate to severe acute exacerbations of chronic obstructive pulmonary disease(AECOPD)complicated with type Ⅱ re-spiratory failure.Methods:A total of 120 patients with moderate to severe AECOPD accompanied by type Ⅱ respiratory failure were selected,who were admitted to the emergency department and ICU from November 2020 to October 2022.Patients were divided into a control group and an observation group based on whether BiPAP non-invasive ventilator was used for ventilation assistance,with 60 cases in each group.Patients in the control group did not use BiPAP non-invasive ventilators for assisted ventilation(30 cases in moderate and 30 cases in severe),and patients in the observation group used BiPAP non-invasive ventilators for assisted ventilation(30 cases in moderate and 30 cases in severe).The levels of serum MR-pro ADM,arterial blood gas and pulmonary function were measured before treatment,3 days and 7 days after treatment in the two groups.Results:The levels of serum MR-proADM in the observation group at 3 days and 7 days af-ter treatment were(200.88±45.98)ng/L,(124.66±34.54)ng/L,respectively,which were significantly lower than those in the control group at 3 days and 7 days after treatment([255.42±55.56]ng/L,[191.98±47.44]ng/L)(P＜0.05).The levels of arterial blood gas PaCO2 in the observation group were(60±11)mmHg(1 mmHg=0.133 kPa),(44±10)mmHg,respectively,which were significantly lower than those in the control group([69±10]mmHg,[64± 9]mmHg)at 3 days and 7 days after treatment(P＜0.05).The FEV1％levels in the observation group were(58.63± 3.85)％,(68.98±4.32)％,respectively,which were significantly higher than those in the control group([51.65± 3.81]％,[56.42±3.63]％)at 3 days and 7 days after treatment(P＜0.05).Conclusion:BiPAP could significantly de-crease the levels of serum MR-proADM and arterial blood gas analysis of PaCO2 in patients with moderate to severe AE-COPD complicated with type Ⅱ respiratory failure,and improve the pulmonary function.
mid-regional proadrenomedullinblood gas analysislung functionacute exacerbations of chronic ob-structive pulmonary disease
NETL
NSTL
万方数据
