Effect of prophylactic antiepileptic treatment on the prognosis of out-of-hospital cardiac arrest patients
Objective:To explore the preventive use of antiepileptic drugs to treat rhythmic and periodic elec-troencephalography(EEG)patterns to improve the ending of the nervous system for 3 months after out-of-hospital cardiac arrest(OHCA).Methods:Select 218 OHCA patients(GCS ≤8)from December 2021 to September 2023 in EICU of Handan Middle hospital.1∶1 randomly allocated as standard therapy group and antiepileptic therapy group.Within 24 h of return of spontaneous circulation,continuous EEG monitoring will be applied.The stand-ard treatment group is given standardized treatment,while antiepileptic therapy group start elevation ladder pre-vention of anti-epilepsy within 3 h rhythmic and periodic EEG patterns appeared at least for 48 h.Observe the clinical ending of the survivors 3 months after discharge.Results:The incidence of poor prognosis(CPC≥ 3)in the standard treatment group was 89.9％,and the antiepileptic treatment group was 78.9％,the difference was sta-tistically significant(P=0.0251).The EICU hospitalization and mechanical ventilation time of the anti-epilepsy treatment group were slightly longer than the standard treatment group,but the difference was not statistically significant(P＞0.05).Conclusion:Preventive use of antiepileptic drugs to treat rhythmic and periodic EEG pat-terns can improve the end of the nervous system for 3 months after out-of-hospital cardiac arrest.
NETL
NSTL
万方数据
