Predictive value of the ROX-HR index for mortality in patients with sepsis
Objective:To investigate the predictive value of the ROX-HR index for 28-day mortality in sepsis patients.Methods:A total of 178 patients with sepsis admitted to our hospital from October 2022 to October 2023 were selected for this retrospective study.ROX-HR index and ROX index were calculated from respiration,heart rate,oxygen saturation,and inspired oxygen concentration recorded within 2 hours after admission.The worst ROX-HR index and ROX index within 2 hours were recorded.Logistic regression modeling was used to determine the independent predictors associated with 28-day mortality in sepsis patients.The predictive value of the ROX-HR index for sepsis patients was evaluated using the Receiver operator characteristic(ROC)curve.The predictive value of ROX-HR index for mortality in sepsis patients was determined using the Youden index.Based on the op-timal cut-off value of ROX-HR index determined by the Youden index,all sepsis patients were divided into the high ROX-HR index group and the low ROX-HR index,and the Kaplan-Meier survival curves were plotted to an-alyze the relationship between ROX-HR index and the survival status of the two groups of patients.Results:Higher APACHE Ⅱ score,higher lactate and lower ROX-HR index were suggested to be independently associat-ed with the 28-day mortality in sepsis patients by logistic regression analysis.The results of area under curve(AUC)of ROX-HR index,APACHE Ⅱ,lactate and ROX index were 0.722(95％CI:0.641-0.802)、0.758(95％CI:0.685-0.830)、0.674(95％CI:0.585-0.762)and 0.684(95％CI:0.600-0.768),respectively.Patients were categorized into high and low ROX-HR groups based on the best cut-off value(6.3)of ROX-HR for predicting 28-day mortality in sepsis patients,and analysis of the Kaplan-Meier curves showed that the cumulative survival rate in the high ROX-HR index group was significantly higher than that in the low ROX-HR index group(79.37％vs 34.62％,P＜0.01).The AUC of ROX-HR index for patients with septic shock was 0.607.Conclu-sion:ROX-HR index was significantly lower in the death group than in the survival group,and ROX-HR index＜6.3 was an independent predictor of 28-day mortality in sepsis patients.The ROX-HR index has poor predictive value in patients with septic shock.
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