Integration of heparin-binding protein and interleukin-6 in the early prediction of mortality in sepsis
Objective:To investigate the predictive value of heparin-binding protein(HBP)and interleukin-6(IL-6)in sepsis.Methods:A total of 119 adult patients with sepsis were enrolled in this retrospective study who admitted to Department of Emergency Medicine of the Affiliated Huaian No.1 People's Hospital of Nanjing Medi-cal University from September 2021 to May 2023.They were divided into survival group and death group accord-ing to survival status.HBP,IL-6 and other clinical data of two groups were analyzed and compared.Multivariate Cox regression were used to analyze the influence of HBP and IL-6 on prognosis,and forest plots were drawn to compare the independent prognostic factors.Kaplan-Meier(K-M)survival analysis was performed for patients.Re-sults:The HBP and IL-6 of the death group was significantly higher than those of the survival group(P＜0.05).Cox regression analysis evidenced admission HBP more than 161.77 ng/mL(HR=4.850,95％CI:1.918-12.260,P＜0.001)and IL-6 more than 119.11 pg/mL(HR=4.208,95％CI:1.321-13.410,P=0.015)as independent risk factors for hospitalization motality of patients with sepsis.K-M survival analysis showed that hospitalization motality risk of patients with HBP＞161.77 ng/mL and IL-6＞119.11 pg/mL was higher(HR:7.87,95％CI:3.23-19.18,P＜0.000 1).Integration of HBP and IL-6 prognosticated mortality with sensitivi-ty,specificity,positive predictive value,negative predictive value,positive likelihood ratio and negative likelihood ratio 66.7％,93.3％,77.1％,89.3％,9.96,0.36,respectively.Conclusion:The levels of HBP and IL-6 are in-dependent risk factors for sepsis patients.And the integration of the two had good predictive value for prognosis of sepsis patients.
NETL
NSTL
万方数据
