Value of peripheral blood adhesion molecules and coagulation function indexes in the diagnosis of recent intracranial infection and prognosis prediction in patients with acute cerebral infarction
Objective:To explore the value of peripheral blood adhesion molecules and coagulation function in-dexes in the diagnosis of recent intracranial infection and prognosis prediction in patients with acute cerebral infarc-tion(ACI).Methods:A retrospective analysis was performed on the clinical data of 80 patients with ACI admitted to the 731 Hospital of China Aerospace Science and Industry Corporation between June 2020 and June 2023.Ac-cording to presence or absence of postoperative intracranial infection,they were divided into infection group(n=48)and non-infection group(n=32).According to the prognosis within 3 months,they were divided into poor prognosis group(n=23)and good prognosis group(n=25).The changes of peripheral blood adhesion molecules(adhesion molecule integrin αM[CD11b],integrin beta-2[CD18])and coagulation function indexes(prothrombin time[PT],fibrinogen[FIB])in different groups were analyzed.The accuracy of serum CD11b,CD18,PT and FIB in the diagnosis of secondary intracranial infection and prognosis prediction in ACI patients was evaluated by area under the receiver operating characteristic(ROC)area under the curve(AUC).Results:The levels of CD11b,CD18,PT and FIB in infection group were significantly higher than those in non-infection group,and the differ-ence was statistically significant(P＜0.05),and which were significantly higher in poor prognosis group than those in good prognosis group,and the difference was statistically significant(P＜0.05).The best cut-off values of CD11b,CD18,PT and FIB in the diagnosis of intracranial infection were 18.060％,29.140％,13.235 s and 4.600 g/L,respectively.AUC of combined detection was 0.953,greater than that of any single index(0.712,0.677,0.655,0.661).The diagnostic specificity of combined detection was 87.50％,higher than that of any sin-gle index(71.43％,65.38％,60.07％,61.54％).The diagnostic sensitivity of combined detection was 91.67％,higher than that of any single index(69.09％,72.22％,72.55％,70.37％).Conclusion:Peripheral blood adhe-sion molecules and coagulation function indexes have good diagnostic value for recent intracranial infection and therefore have certain predictive value for prognosis in ACI.
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