目的:探讨中性粒细胞/淋巴细胞比值(neutrophil-lymphocyte ratio,NLR)对院内心跳骤停(in-hos-pital cardiac arrest,IHCA)患者恢复自主循环(return of spontaneous circulation,ROSC)不良预后的预测价值.方法:采用回顾性分析方法,根据纳入与排除标准收集2021年10月—2023年9月收住长治市人民医院重症医学科的IHCA患者ROSC且住院≥24 h,根据最终结局分为存活组和死亡组.收集患者的一般资料、急性生理学与慢性健康状况评分 Ⅱ(acute physiology and chronic health evaluation,APACHE Ⅱ)及 ROSC 后 24 h 内最初实验室指标如白细胞计数(WBC)、中性粒细胞绝对值、淋巴细胞绝对值、酸碱度(PH)、血乳酸(Lac)、白蛋白,计算NLR.比较两组指标,将有统计学意义的指标进行二元多因素logistic回归分析,绘制受试者工作曲线(ROC曲线)进一步评估NLR对疾病预后的预测价值.结果:本研究共纳入137例,存活组47例,死亡组90例,死亡率为65.7％.两组患者年龄、性别、基础疾病、连续性肾脏替代治疗及体外膜肺氧合使用率、心源性、电除颤及肾上腺素(＞5 mg)、WBC均差异无统计学意义(P＞0.05).与存活组相比,死亡组心肺复苏时间、中性粒细胞绝对值、NLR、A-PACHE Ⅱ、Lac明显升高,而淋巴细胞绝对值、PH、白蛋白水平明显下降,差异有统计学意义(P＜0.05).二元多因素logistic回归分析结果显示:NLR、APACHE Ⅱ、复苏时间、白蛋白均是ROSC患者预后不良的独立危险因素.ROC曲线分析显示:NLR与APACHE Ⅱ预测价值相当,其次为复苏时间、白蛋白.曲线下面积(AUC)分别为0.825、0.837、0.774、0.696,当截断值分别为6.16、24.5、18.0、31.15时灵敏度和特异度分别为80.9％和75.6％、77.8％和 77.2％、96.7％和 53.2％、76.6％和 65.6％,且 NLR 联合复苏时间时 AUC 更高,为 0.891,灵敏度和特异度分别为83.3％和83.0％.结论:对ROSC的IHCA患者预后NLR与APACHE Ⅱ的预测价值相当,且NLR简单、经济,联合复苏时间预测价值更高,可用于临床治疗决策.
The prognostic value of neutrophil-lymphocyte ratio in patients with return of spontaneous circulation after in-hospital cardiac arrest
Objective:To investigate the prognostic value of the neutrophil-lymphocyte ratio(NLR)for adverse outcomes in patients with return of spontaneous circulation(ROSC)after in-hospital cardiac arrest(IHCA).Meth-ods:A retrospective analysis was performed.The patients with ROSC after IHCA who were admitted to the De-partment of Critical Care,Changzhi People's Hospital and hospitalized for ≥24 hours from October 2021 to Sep-tember 2023 were enrolled according to the inclusion and exclusion criteria.They were divided into survival group and death group according to the final outcome.General information,acute physiology and Chronic Health Evalu-ation Ⅱ(APACHE Ⅱ)and initial laboratory parameters such as white blood cell(WBC),absolute neutrophil,absolute lymphocyte,PH,blood lactic acid(Lac),albumin within 24 hours after ROSC were collected.Calculate the NLR.The two groups parameters were compared,and the statistical significance was analyzed by multivariate logistic regression.The receiver operating characteristic(ROC)curve was drawn to further evaluate the prognos-tic value of NLR.Results:A total of 137 patients were enrolled in this study,47 in the survival group and 90 in the death group.The mortality rate was 65.7％.There were no significant differences in age,sex,underlying diseases,CRRT,ECMO usage,cardiogenic,defibrillation,epinephrine(＞5 mg)and WBC between the two groups(P＞0.05).Compared those in the survival group,the time of CPR,absolute value of neutrophil,NLR,APACHE Ⅱ and Lac in the death group were significantly increased,while the absolute value of lymphocyte,PH and albumin level were significantly decreased,with significant differences(P＜0.05).Multivariate logistic re-gression analysis showed that NLR,APACHE Ⅱ,time of resuscitation and albumin were independent risk fac-tors for poor prognosis of ROSC.ROC curve analysis showed that NLR had the same predictive value as A-PACHE Ⅱ,followed by recovery time and albumin.The area under the curve(AUC)was 0.825,0.837,0.774 and 0.696,respectively.When the cut-off values were 6.16,24.5,18.0 and 31.15,the sensitivity and specificity were 80.9％and 75.6％,77.8％and 77.2％,96.7％and 53.2％,76.6％and 65.6％,respectively.When NLR combined resuscitation time,the AUC was higher(0.891)and the sensitivity and specificity were 83.3％and 83.0％,respectively.Conclusion:The prognostic value of NLR in IHCA patients with ROSC is similar to that of APACHE Ⅱ,and NLR is simple,economical.When NLR combined resuscitation time,the predictive value is higher,which can be better used in clinical treatment decision.
cardiac arrestcardio-pulmonary resuscitationreturn of spontaneous circulationneutrophil lymphocyte ratio
NETL
NSTL
万方数据
