The value of the ratio of neutrophil count to lymphocyte count and platelet count combined with blood lactic acid in predicting AKI in patients with multiple injuries
Objective:To investigate the value of neutrophil count to lymphocyte and platelet count ratio(N/LPR)combined with blood lactic acid in predicting acute kidney injury(AKI)in patients with multiple injuries.Methods:The clinical data of 87 patients with severe multiple injuries admitted to the emergency Department of the Eighth Peoples Hospital of Nanning,Guangxi from February 2021 to October 2023 were retrospectively ana-lyzed.According to whether AKI occurred during hospitalization,the patients were divided into AKI group and non-AKI group.Trauma severity score,neutrophil count,lymphocyte count,platelet count,serum lactic acid and other indicators were compared between the two groups at admission.logistic regression was used to screen the factors affecting the occurrence of AKI in patients.ROC curve was used to analyze the predictive value of N/LPR,blood lactic acid and their combination on the occurrence of AKI.Results:Before treatment,there were no signifi-cant differences in age,gender,disease,white blood cell count,hemoglobin count and serum creatinine between the two groups(all P＞0.05).ISS score,ratio of neutrophil count to lymphocyte and platelet count,blood lactic acid and C-reactive protein in AKI group were higher than those in non-AKI group(all P＜0.05).The mean arte-rial pressure on admission was lower than that in non-AKI group(P＜0.05).logistics regression analysis showed that N/LPR and blood lactic acid were independent risk factors for AKI in patients with multiple injuries(P＜0.05).ROC analysis showed that with N/LPR＞9.06,the AUC of AKI occurance in patients with multiple inju-ries was 0.726 and the sensitivity and specificity were 86.7％,62.9％respectively.With blood lactic acid＞2.58 mmol/L,the sensitivity and specificity of AKI in patients with multiple injuries were 90.7％,54.2％,and the AUC was 0.738.Combined both indicators,the AUC of AKI in patients with multiple injuries was 0.869 and the sensitivity and specificity were 86.7％,73.6％respectively.Conclusion:Elevated N/LPR and blood lactic acid are independent risk factors for AKI in patients with multiple injuries.N/LPR and blood lactic acid can effectively predict AKI in patients with multiple injuries,which is of great clinical significance for clinical prevention and treatment of AKI.
neutrophil count to lymphocytes and platelets count ratiopolytraumaacute kidney injurypre-diction
NETL
NSTL
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