Analysis of the role of jellyfish toxin phospholipase A2 in inflammation induced by jellyfish sting
Objective:To investigate the role of jellyfish phospholipase A2(PLA2)structural relationships in the systemic inflammatory response syndrome caused by jellyfish stings.Methods:Based on the transcriptomic and proteomic data of various jellyfish tentacle tissues,the physicochemical properties,hydrophilicity,signal pep-tide,secondary structure,and tertiary structure were analyzed and predicted via bioinformatics analysis.Results:The obtained amino acid sequences of various jellyfish PLA2,their proteins are mainly characterised by low molec-ular weight,and most of the proteins in the hydrophilicity analysis have excellent hydrophilicity characteristics,considering that the protein secondary and tertiary structures exhibit significant distortion and folding.Those rich structural features play an important role in their biological activities.And STRING database-based bioinformatics analysis found that those sequences all interact with PLA2G15,PLA2G3,ADD1 and other proteins by construc-ting protein interaction network,and this type of proteins plays an important role in the production of various in-flammatory mediators.Conclusion:Jellyfish PLA2 may have induced the inflammatory response in the systemic inflammatory response syndrome caused by jellyfish stings through pathways such as Arachidonic acid metabo-lism,providing reference value for the treatment of jellyfish stings.
NETL
NSTL
万方数据
