Analysis of the risk factors for acute kidney injury in patients with snakebite
Objective:To analyze the risk factors associated with acute kidney injury in patients with snake-bites in Chongqing and surrounding areas.Methods:From January 2018 to January 2023,156 cases of snakebite patients treated in the emergency department of our hospital were included in the study.The average age of pa-tients with snakebites was(51±16)years.The patients were divided into the acute kidney injury group(26 cases)and the non-acute kidney injury group(130 cases)based on whether acute kidney injury occurred.A comparative a-nalysis was conducted on gender,age,pre-hospital time,bite site,leukocyte count,hemoglobin levels,myohae-moglobin,cardiac enzyme profile,liver function and coagulation function between the two groups.Additionally,logistic regression models were employed to analyze the relevant risk factors associated with acute kidney injury.Results:Between the acute kidney injury group and non-acute kidney injury group,hemoglobin,creatine kinase isoenzyme,gender,alanine aminotransferase,aspartate aminotransferase,prothrombin time,activated partial thromboplastin time,abnormal liver function and coagulation function(P＜005).However,the two groups showed no difference in age,leukocyte count,haemoglobin,creatine kinase and bite site(P＞005).The pre-hos-pital time of patients with acute kidney injury was longer than that of patients with non-acute kidney injury(P＜0.05).Acute kidney injury patients exhibited relatively higher rates of abnormal liver and coagulation function,as well as elevated leukocyte count,all with statistical significance(P＜0.05).logistic regression analysis showed that gender,treatment time,leukocyte count,hemoglobin,liver function,and coagulation function were found to be statistical significance(P＜0.05).Pre-hospital time,abnormal liver function,and coagulation function were found to be statistical significance(P＜0.05).Conclusion:Gender,pre-hospital time,leukocyte count,hemoglo-bin,liver function,and coagulation function are risk factors for the development of acute kidney injury induced by snakebites.Furthermore,Pre-hospital time,abnormal liver function and abnormal coagulation function are inde-pendent risk factors for acute kidney injury following snakebites.
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