目的:探讨单核细胞与高密度脂蛋白比值(monocyte to high-density lipoprotein ratio,MHR)、白蛋白及球蛋白比值(albumin to globulin ratio,AGR)在急性 ST 段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者病情评估及预后预测方面的价值.方法:选取我院2021年6月-2023年6月STEMI患者146例为研究组,同期选取稳定型心绞痛患者58例为对照组.比较两组MHR、AGR水平及不同病情危重程度STEMI患者MHR、AGR水平,Cox回归分析STEMI患者预后影响因素,受试者工作特征(receiver operating characteristic,ROC)曲线分析MHR、AGR对STEMI患者预后的预测价值.结果:研究组AGR低于对照组,MHR高于对照组,均差异有统计学意义(P＜0.05);随STEMI患者病情加重,MHR水平逐渐升高,AGR水平逐渐降低(P＜0.05);Cox回归分析显示,高水平低密度脂蛋白胆固醇、脑利钠肽、MHR与低水平左室射血分数、白蛋白、AGR均为STEMI患者预后不良独立危险因素(P＜0.05);ROC显示,MHR、AGR联合预测STEMI患者预后的AUC值0.978最大,灵敏度为96.70％,特异度为92.73％.结论:STEMI患者MHR、AGR异常表达,与患者病情程度有关,且对患者预后具有良好预测价值.
The value of monocyte to high-density lipoprotein ratio and albumin to globulin ratio in the assessment and prognosis of patients with acute ST-segment elevation myocardial infarction
Objective:To investigate the value of monocyte to high-density lipoprotein ratio(MHR)and albu-min to globulin ratio(AGR)in the assessment and prognosis of acute ST-segment elevation myocardial infarction(STEMI).Methods:One hundred and forty-six STEMI patients in our hospital from June 2021 to June 2023 were selected as the study group,and 58 patients with stable angina pectoris were selected as the control group during the same period.The MHR and AGR levels of the two groups and the MHR and AGR levels of STEMI patients with different severity were compared.Cox regression analysis was conducted to analyze the prognostic factors of STEMI patients.The predictive value of MHR and AGR in STEMI patients was analyzed by receiver operating characteristic(ROC)curve.Results:The AGR of study group was lower than that of control group,and the MHR was higher than that of control group(P＜0.05).With the aggravation of STEMI patients,MHR level was grad-ually increased and AGR level was gradually decreased(P＜0.05).Cox regression analysis showed that high levels of low-density lipoprotein cholesterol,B-type natriuretic peptide,MHR and low levels of left ventricular ejection fraction,albumin,AGR were independent risk factors for poor prognosis in STEMI patients(P＜0.05).ROC showed that the combination of MHR and AGR predicted the prognosis of STEMI patients with the largest AUC value of 0.978,corresponding sensitivity of 96.70％,specificity of 92.73％.Conclusion:The abnormal expres-sion of MHR and AGR in STEMI patients is related to the severity of patients'disease,and has good prognostic value for patients.
ratio of monocyte to high-density lipoproteinalbumin and globulin ratioacute ST elevation my-ocardial infarctionstate of the diseaseprognosis
万方数据
维普
