目的:探讨预后营养指数(prognostic nutritional index,PNI)与脓毒症休克预后的相关性及其对脓毒症休克患者重症监护病房(intensive care unit,ICU)28 d死亡率的预测价值.方法:采用回顾性分析方法,分析安徽医科大学第二附属医院重症医学科2022年1月-2022年12月收治的脓毒症休克患者.根据患者在ICU入院28 d内的生存状况,将其分为生存组和死亡组,收集并分析相关临床和实验室资料.单因素和多因素logis-tic 回归分析PNI与脓毒症休克预后的关系.受试者工作特征曲线(receiver operating characteristic,ROC)和曲线下面积(area under the curve,AUC)评价PNI对脓毒症休克患者ICU 28 d死亡率的预测价值,使用最大约登指数确定PNI截断值,根据截断值将患者分为两组,采用Kaplan-Meier法绘制生存曲线比较两组患者生存率.结果:共纳入88例脓毒症休克患者,生存组57例,死亡组31例,病死率为35.2％.死亡组的白蛋白、外周血淋巴细胞计数及PNI均低于生存组,差异有统计学意义(P＜0.05).死亡组的尿素氮、乳酸、SOFA评分、APACHE Ⅱ评分及慢性肾脏病比例均高于生存组,差异有统计学意义(P＜0.05).单因素和多因素logistic回归显示PNI与ICU 28 d死亡率独立相关(OR=0.84,95％CI:0.74～0.95,P＜0.01).ROC分析显示PNI预测脓毒症休克患者 ICU 28 d 死亡率的 AUC 为 0.77(95％CI:0.67～0.88,P＜0.01).Kaplan-Meier 生存曲线分析显示 PNI＞30.7组ICU 28 d生存率显著高于PNI≤30.7组,差异有统计学意义(P＜0.01).结论:PNI与脓毒症休克患者的预后存在独立相关性,且对脓毒症休克患者ICU 28 d死亡率有一定的预测价值.
Predictive value of the prognostic nutritional index for 28-day ICU mortality in patients with septic shock
Objective:To investigate the relationship between the prognostic nutritional index(PNI)and prog-nosis in septic shock,and its predictive value for 28-day intensive care unit(ICU)mortality in patients with septic shock.Methods:A retrospective analysis was conducted on patients with septic shock admitted to the ICU of the Second Affiliated Hospital of Anhui Medical University from January to December 2022.Based on the survival status within 28 days after ICU admission,patients were divided into survival and death groups.Clinical and labo-ratory data were collected and analyzed.Univariate and multivariate logistic regression analyses were used to as-sess the association between PNI and prognosis in septic shock.The predictive value of PNI for 28-day ICU mor-tality in patients with septic shock was evaluated using the receiver operating characteristic(ROC)curve and area under the curve(AUC).The optimal PNI cut-off value was determined using the maximum Youden index,and patients were divided into two groups based on this threshold.The Kaplan-Meier method was used to plot survival curves and compare the survival rates between the two groups.Results:A total of 88 patients with septic shock were included,with 57 cases in the survival group and 31 cases in the death group(35.2％).The death group had significantly lower peripheral blood lymphocyte count,albumin level,and PNI compared to the survival group(P＜0.05).In addition,blood urea nitrogen,lactate,SOFA scores,APACHE H scores,and the proportion with chronic kidney disease were significantly higher in the death group(P＜0.05).Both univariate and multivariate lo-gistic regression analyses showed that PNI was independently associated with 28-day ICU mortality(OR=0.84,95％CI:0.74-0.95,P＜0.01).ROC analysis revealed that PNI had an AUC of 0.77(95％CI:0.67-0.88,P＜0.01)in predicting 28-day ICU mortality in patients with septic shock.Kaplan-Meier survival analysis indica-ted that the 28-day ICU survival rate was significantly higher in the group with PNI＞30.7 compared with the group with PNI≤30.7(P＜0.01).Conclusion:PNI is independently associated with the prognosis of patients with septic shock and has a significant predictive value for 28-day ICU mortality.
septic shockprognostic nutritional index28-day ICU mortalitypredictive value
NETL
NSTL
万方数据
