The evaluation value of Delta-like ligand 1 levels in risk stratification and prognosis of sepsis patients
Objective:To explore the role of plasma Delta-like ligand 1(DLL1)levels in assessing the severity and prognostic value of sepsis in patients.Methods:Clinical data of 86 patients with sepsis were collected and di-vided into sepsis group(n=40)and septic shock group(n=46)based on the severity of their condition after admis-sion.According to the survival status of patients 28 days later,86 patients were divided them into a survival group(n=53)and a death group(n=33).Baseline data,biochemical index,sequential organ failure assessment(SOFA)score,acute physiology and chronic health score system Ⅱ(APACHE Ⅱ)score,and plasma DLL1 levels were compared.The correlation between DLL1 and SOFA score,APACHE Ⅱ score,C-reactive protein(CRP),pro-calcitonin(PCT),interleukin-6(IL-6)were analyzed,The ROC curve was used to analyze the value of disease se-verity and prognosis.Results:Compared with sepsis patients,the plasma DLL1 levels in the septic shock group were significantly increased(t=9.819,P＜0.001),and the plasma DLL1 levels in deceased patients were higher than those in surviving patients(t=1.976,P=0.04).Pearson correlation analysis showed that plasma DLL1 lev-els were significantly positively correlated with SOFA score,APACHE Ⅱ score,and IL-6 in sepsis patients(r2=0.130 1,P＜0.001;r2=0.074 9,P=0.010 7;r2=0.073 9,P=0.037 0),Multivariate analysis showed that DLL1 was an independent risk factor for judging the severity of sepsis,with an OR of 1.369(95％CI:1.151-1.628).The ROC curve showed that the AUC of plasma DLL1 level for judging the severity of sepsis was 0.928(95％CI:0.877-0.979),with a cut-off value of 47.105 ng/mL,sensitivity of 0.913,and specificity of 0.825.The mortality of the DLL1 high-level group was significantly higher than that of the DLL1 low-level group,and the difference was statistically significant(P=0.002).Conclusion:DLL1 has evaluative value in assessing the se-verity and prognosis of sepsis.
sepsisDelta-like ligand 1the severity of the conditionprognosis
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NSTL
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