高甘油三酯血症性急性胰腺炎发病机制研究进展
Advances in the pathogenesis of hypertriglyceridemia acute pancreatitis
陈楚佳 1王美堂2
作者信息
- 1. 海军军医大学第一附属医院全科医学科(上海,200433)
- 2. 海军军医大学第一附属医院急诊科
- 折叠
摘要
急性胰腺炎是一种常见的炎性胃肠道疾病,重症急性胰腺炎死亡率高且无有效的特异性治疗.近年来,高脂血症性急性胰腺炎的发病率不断上升且分型较重,但甘油三酯如何影响AP的发病及发展机制尚未完全阐明.最近研究发现甘油三酯的水解产物之一游离脂肪酸可以引起胰腺腺泡细胞中的多种细胞事件,影响急性胰腺炎的发生发展.本文将对游离脂肪酸的细胞病理作用及其对胰腺微循环的影响、甘油三酯水平与急性胰腺炎发病和严重程度的关系等方面进行综述,以期为高脂血症性急性胰腺炎治疗及预后判断提供新思路.
Abstract
Acute pancreatitis is a common inflammatory gastrointestinal disease,and severe acute pancreati-tis has a high mortality rate and no effective specific treatment.In recent years,the incidence of hyper triglyceri-demic acute pancreatitis has been on the rise,and it has a variety of types.However,how triglyceride affects the pathogenesis and development mechanism of acute pancreatitis has not been fully clarified.Recent studies have shown that free fatty acids,one of the hydrolyzed products of triglyceride,may cause multiple cellular events in pancreatic acinar cells,which could affect the occurrence and development of acute pancreatitis.This paper will summarize different aspects such as Cytopathological effect of free fatty acids and its effect on pancreatic microcir-culation,the relationship between triglyceride level and the incidence and severity of acute pancreatitis and so on,in order to provide new ideas for the treatment and prognosis of hyper triglyceridemic acute pancreatitis.
关键词
急性胰腺炎/脂肪酸/高甘油三酯血症/发病机制Key words
acute pancreatitis/fatty acids/hypertriglyceridemia/pathogenesis引用本文复制引用
基金项目
海军军医大学第一附属医院"234学科攀峰计划"项目(2020YXK038)
出版年
2024
NETL
NSTL
万方数据