Comparison of analgesic pumps with different parameters of nalbuphine for postoperative analgesia after cesarean section
Objective To study the effect of patient-controlled intravenous analgesia(PCIA)with nalbuphine under different parameter settings on postoperative analgesia after cesarean section.Methods A total of 179 parturients after cesarean section,aged 18-45 years,BMI 20-35 kg/m2,ASA physical statusⅠ or Ⅱ,were selected to receive PCIA(nalbuphine 2 mg/kg+tropisetron 8 mg/100 ml,15-minute inter-val,maximum limit 10 ml/h).The parturients were randomly divided into three groups:control group(group C,receiving continuous infusion rate 2 ml/h and bolus dose 2 ml,n=60),low background group(group L,receiving continuous infusion rate 1 ml/h and bolus dose 3 ml,n=62),and no background group(group N,no continuous infusion rate,bolus dose 4 ml,n=57).VAS scores at rest and active,and nalbuphine consumption were recorded at 2,6,12,24,and 48 hours after operation.The press condic-tion of PCIA within 48 hours after operation,the time of first flatus and postoperative hospital stay,Ramsay sedation scale(RSS)scores,and adverse reactions such as postoperative nausea and vomiting,dizziness,and infection were also recorded.Results Compared with group C,VAS pain scores at rest at 6 and 12 hours after operation were significantly decreased in group N(P＜0.05),nalbuphine consumption at 24 and 48 hours after operation was significantly decreased in groups L and N,the time of first flatus and the incidence of dizziness were also significantly reduced in groups L and N(P＜0.05),and the length of postoperative hospital stay was significantly shorter in group N(P＜0.05).Compared with group L,the VAS pain scores at resting and active 12 hours after surgery in group N were significantly increased,the consumption of nalbuphine at 48 hours after surgery was significantly decreased,the total and effective times of compressions were significantly increased,and the first exhaust time was significantly shortened(P＜0.05).There were no significant differences in RSS scores and the incidence of postoperative nausea and vomiting,infection among the three groups.Conclusion Nalbuphine PCIA with low background(1 ml/h)provides satisfactory analgesic effect after cesarean section,reduces the dosage of nalbuphine and the inci-dence of opioid-related adverse reactions and shortens the flatus time,which can be used as the preferred parameter setting for nalbuphine PCIA after cesarean section.
万方数据
维普
