Research progress on the mechanism of Wnt signaling pathway in peripheral neuropathic pain
Neuropathic pain is the pain syndrome caused by damage or disease of the somatosensory system,clinically,the common type is peripheral neuropathic pain(pNP),mainly manifested as spontane-ous pain,allodynia,hyperalgesia and paresthesia,with complex and controversial pathogenesis.At present,clinical treatment is mainly based on drugs,with poor effect and more adverse events.Wingless-type MMTV integration site family(Wnt)signaling pathway plays an important role in cell proliferation and differentia-tion in neurodevelopment and can participate in the occurrence of pNP by regulating nerve injury repair.This article reviews the relationship between Wnt signaling pathway and pNP,in order to provide guidance for more safe and effective therapeutic targets.
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