Sepsis is a common complication of combat trauma and injuries,and is one of the com-mon causes of acute lung injury.Sepsis-induced acute lung injury is a clinical syndrome characterized by hy-poxemia and dyspnea,which can progress to acute respiratory distress syndrome.The pathogenesis of sepsis-induced acute lung injury is not fully understood,and there is still no effective targeted intervention.Pyrop-tosis is a form of programmed cell death characterized by membrane perforation and inflammatory factor releasing.In recent years,studies have found that pyroptosis plays an important role in the occurrence and development of sepsis-induced acute lung injury and is a potential therapeutic target.In this article,the mo-lecular mechanism of pyroptosis and the mechanism of pyroptosis of different types of cells involved in sepsis-induced acute lung injury are summarized,in order to provide theoretical basis for new treatment strategies for sepsis-induced acute lung injury.
关键词
细胞焦亡/急性肺损伤/脓毒症/程序性细胞死亡
Key words
Pyroptosis/Acute lung injury/Sepsis/Programmed cell death
维普
万方数据