Effect of flurbiprofen axetil on lung function in patients undergoing thoracoscopic right lung lobecto-my during one-lung ventilation
Objective To observe the effect of flurbiprofen axetil on lung oxygenation function,re-spiratory mechanics and pulmonary complications in patients undergoing thoracoscopic right lung lobectomy with endobronchial blockers during one-lung ventilation(OLV).Methods Sixty patients scheduled for elective thoracoscopic right lung lobectomy with endobronchial blockers for OLV,25 males and 35 females,aged 35-64 years,BMI 18-28 kg/m2,ASA physical status Ⅰ or Ⅱ,were randomly allocated into two groups:the flurbiprofen axetil group(group F)and the control group(group C),30 patients in each group.In group F,flurbiprofen axeil 1.0 mg/kg was injected intravenously 15 minutes before anesthesia induction,while group C was not treated.Blood gas analysis was performed in 2 ml of radial artery 20 minutes before anesthesia induction(T0),30 minutes(T1)and 60 minutes(T2)after OLV,and 15 minutes(T3)after two lung ventilation,then oxygenation index(OI)was calculated respectively and SpO2 was recorded.Pa-rameters of lung mechanics were monitored at T1 and T2 including peak airway pressure(Ppeak),airway platform pressure(Pplat),dynamic lung compliance(Cdyn),and ratio of null lumen volume to tidal vol-ume(VD/VT).The incidence of hypoxemia and the number of remedial cases during OLV were recorded.The postoperative transfer to ICU and complications such as atelectasis,acute lung injury and pneumonia within 72 hours after surgery were recorded.Results Compared with group C,SpO2 at T1,PaO2 and OI at T1—T3,and Cdyn at T1 and T2 were significantly increased in group F(P＜0.05),Ppeak and VD/VT at T1 and T2,Pplat at T2 were significantly decreased in group F(P＜0.05).There were no hypoxemia and remedies occurred during OLV and no patients were transferred to ICU after surgery,no atelectasis,acute lung injury,and pneumonia occurred within 72 hours after surgery between the two groups.Conclusion For patients undergoing OLV with endobronchial blockers undergoing thoracoscopic right lung lobectomy,in-travenous flurbiprofen axetil before induction of anesthesia can help improve lung oxygenation and optimize respiratory parameters during one lung ventilation.
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NSTL
万方数据
维普
