丙泊酚诱导意识消失的脑电机制
Electroencephalographic mechanisms of loss of consciousness induced by propofol
陶飞 1顾卫东1
作者信息
- 1. 200040 上海市,复旦大学附属华东医院麻醉科
- 折叠
摘要
脑电图可以实时连续地记录大脑区域内局部神经元自发的、有节律的电活动,评价大脑功能状态,是一种监测大脑活动的工具,广泛应用于心理学、认知功能以及意识状态等研究领域,为研究全麻药物的作用机制提供了一种新方法.丙泊酚在临床上应用广泛,分子机制已得到深入研究.丙泊酚诱导意识消失的神经脑网络机制目前尚未明确.本文回顾了常用全麻药物丙泊酚诱导意识消失的脑电特征性改变(包括功率谱、复杂度、微状态、功能连通性及脑网络拓扑特征改变)及相应的大脑功能变化,为进一步研究全麻药物的作用机制以及麻醉深度监测提供新思路.
Abstract
Electroencephalography can continuously record the spontaneous and rhythmic electrical activity of local neurons in the brain region in real time and evaluate the functional state of the brain,which is a tool for monitoring brain activity.It has been widely used in the research fields of psychology,cognitive function and consciousness,which provides a new approach to study the mechanism of action of general an-esthetic drugs.Propofol is widely used in clinical practice,and its molecular mechanism has been deeply studied.The neural network mechanism of loss of consciousness induced by propofol is still unclear.This ar-ticle reviews the changes of electroencephalogram characteristics(including power spectrum,complexity,microstate,the functional connectivity,and brain network topology characteristics change)and corres-ponding brain functional changes of loss of conscionsness induced by propofol,the common general anesthet-ic,to provide a new idea for further research on the mechanism of action of anesthetic drugs and the depth of anesthesia monitoring.
关键词
脑电图/丙泊酚/意识消失/大脑功能Key words
Electroencephalography/Propofol/Loss of consciousness/Brain function引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据