Research progress on organ and system protection of remimazolam during perioperative period
Remimazolam is a new,ultra-short-acting benzodiazepine sedative narcotic drug that acts on γ-aminobutyric acid type A receptor(GABAAR).Benzodiazepine receptors on the α subunit of GABAAR have sedative,hypnotic and anxiolytic effects with mild cardiopulmonary effects.The clinical roles of remimazolam in painless endoscopy and general anesthesia have been gradually discovered.Organ protection is the focus of perioperative process,which has a profound impact on postoperative recovery and prognosis.Remimazolam has a protective effect on the nervous system,heart,lung,liver,gastrointestinal tract and other important organs,and its mechanism may be related to anti-inflammation,anti-apoptosis,and stress reduction.This article reviews the organ and systemprotective effect and mechanism of remimazolam,so as to provide some reference for its clinical application.
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