摘要
瑞马唑仑是一种新型的超短效药物,具有起效快、代谢迅速、无蓄积、血流动力学稳定、呼吸抑制轻、不依赖肝肾代谢、代谢产物无活性,且可被特异性拮抗药氟马西尼快速拮抗等优势.由于其良好的作用特点,瑞马唑仑被广泛应用于无痛内镜诊疗、重症监护病房镇静和区域阻滞麻醉辅助镇静.目前瑞马唑仑在全身麻醉中的应用研究逐渐增加,多项研究证实了瑞马唑仑在全身麻醉诱导和维持中安全性与有效性.现就瑞马唑仑的药理学特性及其在麻醉诱导和维持阶段的临床研究作一综述,为其临床麻醉应用提供参考.
Abstract
Remimazolam is a new type of ultra-short-acting benzodiazepine,which has the advanta-ges of rapid onset,rapid metabolism,no accumulation,stable hemodynamics,light respiratory inhibition,independent of liver and kidney metabolism,inactive metabolites,and rapid antagonism by specific antago-nist flumazenil.Due to its functional characteristics,remazolam is extensively utilized in painless endoscopic procedures,sedation in intensive care units,and regional block anesthesia assisted sedation.Currently,the utilization of remazolam in general anesthesia is on the rise,with numerous studies confirming its safety and efficacy in the induction and maintenance of general anesthesia.This article reviews the pharmacological properties of remimazolam and its clinical studies progress on induction and maintenance of general anesthe-sia,and provides reference for its clinical anesthesia application.
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