Association between modified frailty index with prognosis in elderly patients undergoing off-pump coronary artery bypass grafting
Objective To evaluate the association between 5-factor modified frailty index(mFI-5)with prognosis in elderly patients undergoing off-pump coronary artery bypass grafting(OPCABG).Methods Retrospective data were collected from elderly patients who underwent OPCABG between January 2019 and May 2022.The patients were divided into three groups based on preoperative mFI-5:non frailty group(mFI-5=0),pre-frailty group(mFI-5=1),and frailty group(mFI-5 ≥2).Baseline,intraopera-tive,and prognostic indicators of the three groups were collected and compared.Multivariate(logistic re-gression and linear regression)analyses were used to evaluate the association between mFI-5 with prognosis in elderly patients undergoing OPCABG.Results A total of 244 patients were included in the analysis,in-cluding 35 patients(14.3％)in the non-frailty group,82 patients(33.6％)in the pre-frailty group,and 127 patients(52.1％)in the frailty group.Compared with the non-frailty group,the pre-frailty group had higher incidence of acute kidney injury(P＜0.05);the frailty group had lower preoperative LVEF and in-traoperative urine volume,and higher incidence of acute kidney injury and mortality(P＜0.05).Compared with the pre-frailty group,the frailty group had lower intraoperative urine volume,prolonged ICU stay,and higher incidence of mortality(P＜0.05).Multivariate logistic regression analysis showed that for every point increase in mFI-5,the length of stay in ICU was extended by 3.189 days(95％CI 1.457-4.920 days,P＜0.001),and the total length of stay was extended by 2.890 days(95％CI 1.070-4.709 days,P=0.002).Linear regression analysis showed that elevated mFI-5 was associated with complications during hospitalization,including acute kidney injury(OR=1.519,95％CI 1.076-2.145,P=0.017),pulmonary complications(OR=1.453,95％CI 1.075-1.965,P=0.015)and death(OR=3.730,95％CI 1.980-7.027,P＜0.001).Conclusion mFI-5 is a simple and practical screening tool for frail-ty,and using the mFI-5 scale for frailty assessment in elderly patients undergoing OPCABG can screen high-risk patients with poor prognosis during hospitalization.
万方数据
维普
