Efficiency of the application of oliceridine or sufentanil in painless gastroscopy
Objective To compare the application effects of oliceridine or sufentanil combined with propofol respectively in painless gastrointestinal endoscopy.Methods A total of 144 patients,80 males and 64 females,aged 20-64 years,BMI 18.5-28.0 kg/m2,ASA physical statusⅠorⅡ,underwent painless gastrointestinal endoscopy.They were randomly divided into two groups by the random number table method:the oliceridine group(group O)and the sufentanil group(group S),72 patients in each group.Group O was induced with oliceridine at 0.02 mg/kg and propofol at 1.5 mg/kg,while group S was induced with sufentanil at 0.1 μg/kg and propofol at 1.5 mg/kg.HR,MAP,and SpO2 at specific time points:before an-esthesia induction,after induction completion,during gastroscope insertion,3 minutes after gastroscope in-sertion,and upon removal of the gastroscope were recorded.Additionally,record the onset time of anesthe-sia,examination time,wake-up time,time to discharge from the recovery room,additional times of propo-fol,total propofol dosage,and pain scores at the time of awakening and leaving the room.Record the ad-verse reactions including respiratory-related adverse events,hypotension,bradycardia,tachycardia,body movement,coughing during the examination.Conduct a telephone follow-up 24 hours after the operation to record the incidence of abdominal discomfort,nausea and vomiting,fatigue,and patient satisfaction.Results Compared with group S,in group O,SpO2 significantly increased after anesthesia induction,HR significantly slowed down when the gastroscope was inserted,the time to discharge from the recovery room was significantly shortened,the incidences of subclinical respiratory depression,nausea and vomiting were significantly reduced,and the patient satisfaction score was significantly increased(P＜0.05).There were no statistically significant differences between the two groups in anesthesia onset time,examination time,wake-up time,additional times of propofol,total propofol dosage,VAS pain scores at awakening and leaving the room,and the incidences of hypotension,bradycardia,tachycardia,body movement and cough during the examination,as well as the incidences of abdominal discomfort and fatigue during postoperative follow-up.Conclusion Compared with sufentanil,the combination of oliceridine and propofol for painless gastros-copy shows more stable hemodynamics,shorter stay in the recovery room,lower incidence of respiratory-re-lated adverse events and nausea and vomiting,and higher patient satisfaction.It is a safe and effective anes-thesia scheme for painless gastroscopy diagnosis and treatment.
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