Comparison of a single dose of preventive oxycodone and sufentanil on pain during transcatheter ar-terial chemoembolization
Objective To compare the analgesic effects and adverse events of oxycodone and sufentanil in transcatheter arterial chemoembolization(TACE).Methods Forty patients who underwent se-lective TACE under local infiltration anesthesia were enrolled in this study,37 males and 3 females,aged 33-81 years,BMI 18.5-30.0 kg/m2,ASA physical status Ⅰ or Ⅱ.The patients were randomly divided into two groups:the oxycodone group(group O)and the sufentanil group(group S),20 patients in each group.Patients in group O and group S received a single injection of oxycodone 0.1 mg/kg and sufentanil 0.1 μg/kg respectively,15 minutes before TACE.Visual analogue scale(VAS)was performed during the operation and at 1 hour,6,12,and 24 hours after TACE.Pain severity was recorded at each time point.The highest intraoperative pain scores were recorded during the three time points,at immediately after embo-lization,5 minutes after embolization,and 30 minutes after embolization.Need for rescue analgesics,inter-ventional physician satisfaction score,HR and MAP 10 minutes before surgery,5 minutes after emboliza-tion,and 10 minutes after surgery,as well as the occurrence of adverse events such as nausea,vomiting,dizziness,drowsiness,constipation,and dysuria were recorded.Results Compared with group S,the highest intraoperative VAS pain score was lower(P＜0.01),the incidence of intraoperative painless was higher(P＜0.05),and the incidence of intraoperative moderate pain was significantly lower in group O(P＜0.05).There were no significant differences in VAS pain score and pain severity between the two groups 1 hour,6,12,and 24 hours after TACE.Compared with group S,the incidence of perioperative res-cue analgesia in group O was significantly lower(P＜0.01),the interventional physician reported higher degree of satisfaction,MAP was significantly decreased 5 minutes after embolization(P＜0.05).There was no statistically significant difference in perioperative adverse events between the two groups.None of the pa-tients in the two groups had respiratory depression.Conclusion A single dose of preventive oxycodone is superior to sufentanil for TACE-related intraoperative pain control.
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