Comparison on postoperative analgesic effect of intravenous paracetamol and mannitol injection with flurbiprofen axetil on thoracoscopic radical resection of lung cancer
Objective To compare the postoperative analgesic effect of intravenous paracetamol and mannitol injection with that of flurbiprofen axetil on thoracoscopic radical resection of lung cancer.Methods Ninety-seven patients,aged 18-70 years,BMI 18.5-28.0 kg/m2,ASA physical status Ⅰ-Ⅲ,undergoing thoracoscopic radical resection of lung cancer were selected in this study.The patients were divided into two groups:paracetamol and mannitol injection group(group T,n=48)and flurbiprofen ax-etil group(group F,n=49)according to the random number method.Before skin incision,paracetamol and mannitol injection 50 ml(500 mg)was intravenously infused in group T,and the same dose was intra-venously infused every 12 hours within 2 days after operation.In group F,flurbiprofen axetil 50 mg was in-travenously injected before and at the same time point after operation.Patient-controlled intravenous analgesia was performed after surgery and tramadol 50 mg were administered intravenously when patients re-quired remedial analgesia.Visual analog scale(VAS)scores at rest and coughing were recorded at 1 hour,6,12,24,and 48 hours postoperatively to evaluate postoperative pain.The first time to use analgesic pump,the total consumption of oxycodone in the analgesic pump,number of effective and total analgesic pump compressions at first 48 hours postoperatively,the perioperative consumption of sufentanil,time to ex-tubation,hospital length of stay,urine volume,and the incidence of adverse events were also recorded.Results Compared with group F,the VAS score at coughing 6 hours after operation and the incidence of nausea and vomiting were significantly reduced(P＜0.05).The intraoperative urine volume in group T was significantly higher than that in group F(P＜0.05).There were no significant differences between the two groups in the consumption of sufentanil,infusion volume,extubation time,PACU stay time,the first press-ing time,total pressure and effective pressure times,oxycodone consumption,and hospital stay.Conclusion Intravenous paracetamol and mannitol injection can produce an equivalent analgesic effect to flurbiprofen in thoracoscopic radical resection of lung cancer patients and decrease incidence of nausea and vomiting.
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