Progress of injectable hydrogel and the sustained release of local anesthetics
The short-lived effects of local anesthetics limit their use in postoperative pain manage-ment,so prolonging the duration of action of local anesthetics is one of the urgent issues in current clinical work.The use of local anesthetics in combination with adjuvants for prolonged efficacy is also associated with safety hazards and inconsistent results.Local anesthetic slow-release agents not only solve the above problems but also enable on-demand drug delivery and reduce the harm to the human body.Among the cur-rent common local anesthetic slow-release materials,injectable hydrogels have the advantages of high drug loading rate,degradability,stable slow-release,and simple operation.Injectable hydrogel as a slow-release material for local anesthetics not only releases the drug slowly,prolongs the duration of drug action,and provides longer-lasting analgesic effects,but also reduces the total amount of drug used,and more impor-tantly,injectable hydrogel helps to minimize the adverse effects of local anesthetics,such as cardiotoxicity and central neurotoxicity.This article provides a brief overview of recent advances in the study of injectable hydrogels for the slow release of common local anaesthetics.
Local anestheticsHydrogelInjectable hydrogelSustained releasePostoperative pain
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