摘要
报告1例肉芽肿性皮肤松弛症.患者男,46岁.全身松弛性皮肤斑块5年.皮肤科检查:颈部、双上肢、双侧腋窝、双侧腹股沟、胸部、腹部、腰部及背部多发质地软的斑块,表面皮纹皱缩,皮肤松弛.左上肢皮损组织病理检查:(皮肤及皮下脂肪组织)真皮深层及皮下脂肪组织散在多灶性淋巴样细胞、组织细胞浸润伴多核巨细胞形成;真皮内可见多核巨细胞浸润,呈环形排列或聚集于细胞的一侧,周围可见少许淋巴样细胞.免疫组化:淋巴样细胞CD3、CD4及CD5均阳性,CD7及CD8少许阳性,增殖核抗原(Ki-67)阳性(＜5％);CD20、CD30、CD56及颗粒酶B(Gra B)均阴性.诊断:肉芽肿性皮肤松弛症.
Abstract
A case of granulomatous slack skin is reported.A 46-year-old male presented with generalized flaccid skin plaques for 5 years.Dermatological examination showed multiple soft-textured plaques on the neck,both upper limbs,both axillae,both groins,chest and abdomen,and lumbar back,with wrinkled surface skin lines and skin laxity.Histopathological examination of the lesions on the left upper limb revealed multifocal lymphoid cells scattered under the deep dermis and subcutaneous fat tis-sue,and histiocyte infiltration with the formation of multinucleated giant cells.Multinucleated giant cells infiltrated the dermis,and were arranged in a ring or aggregated on one side of the cells,surrounded by a few lymphoid cells.Immunohistochemical staining showed that lymphoid cells were positive for CD3,CD4,CD5,and slightly positive for CD7 and CD8.The cell prolif-eration marker Ki-67 was positive(＜5％);the cells were negative for CD20,CD30,CD56 and granzyme B(Gra B).A diagnosis of granulomatous slack skin was made.
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