皮肤结节性无色素性黑素瘤
Cutaneous nodular amelanotic melanoma:a case report
何萍秀 1夏碧霞 1吴忆 1程丽芳1
作者信息
- 1. 江西省皮肤病专科医院病理科、江西省皮肤病临床医学研究中心、国家皮肤与免疫疾病临床医学研究中心分中心建设单位,江西 南昌 330001
- 折叠
摘要
报告1例皮肤结节性无色素性黑素瘤.患者女,66岁.左小腿屈侧结节9个月.曾于外院手术切除皮损,术后2个月复发.皮肤科检查:左小腿屈侧可见20余个成片分布的粟粒至花生米大红色丘疹及结节,表面光滑,无破溃.皮损组织病理检查:表皮大致正常,真皮内可见肿瘤细胞呈团块状、结节状增生,部分细胞异形性.免疫组化:S-100蛋白、Melan-A及波形蛋白(vimentin)均(+);平滑肌肌动蛋白(SMA)、Friend白血病病毒插入位点1(Fli-1)及人类黑素瘤抗体45(HMB45)均(-).诊断:皮肤结节性无色素性黑素瘤.
Abstract
A case of cutaneous nodular amelanotic melanoma is reported.A 66-year-old female presented with a nodule on the flexor side of the left calf for nine months.The patient had undergone surgical resection in an outside hospital,and the tu-mor recurred two months after the operation.Physical examination showed more than 20 red papules and nodules in miliary or peanut sizes on the flexion side of the left calf,with smooth surface and no ulceration.Histopathological examination revealed that the epidermis was roughly normal,the proliferative tumor cells were clumpy and nodular in the dermis,and some cells were atypical.Immunohistochemical showed the tumor cells were positive for S-100 protein,Melan-A and vimentin;and the tumor cells were negitive for SMA,Fli-1 and HMB45.A diagnosis of cutaneous nodular amelanotic melanoma was made.
关键词
黑素瘤/无色素性/结节性Key words
nodular amelanotic melanoma引用本文复制引用
出版年
2025
NETL
NSTL
万方数据