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主观认知下降的相关因素及其与Alzheimer's病进展的关系

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主观认知下降(SCD)指个体持续自我感知认知功能下降,但相关神经心理检测均在正常范围,可能是Alzheimer's病(AD)疾病谱中最早可被发现的临床前阶段.SCD的影响因素众多,如何早期识别AD进展型SCD以便进行超早期干预是目前研究的重点.本文旨在对SCD的相关概念、临床特征、相关影响因素及其与AD进展的关系进行总结分析,从而为后续的相关研究提供参考.
The related factors of subjective cognitive decline and its relationship with the progression of Alzheimer's disease
Subjective cognitive decline(SCD)refers to self-perceived persistent decline in cognitive function,but the relevant neuropsychological tests remain within the normal range.It is a possible earliest preclinical stage that can be identified in the continuous progressive duration of Alzheimer's disease(AD).Many factors are involved in the occurrence of SCD and how to identify the AD progressive SCD to ultra-early intervention is the focus of current research.This paper aims to summarize and analyze the related concepts,clinical characteristics,related influencing factors,and their relationship with the progression of AD,which may provide a reference for subsequent related studies.

subjective cognitive declinebiomarkerrisk factor

徐敏、徐珊

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100012 北京,解放军总医院京北医疗区内科

清华大学第一附属医院神经内科

主观认知下降 生物标志物 影响因素

2024

临床神经病学杂志
南京医科大学附属脑科医院

临床神经病学杂志

CSTPCD
影响因子:1.778
ISSN:1004-1648
年,卷(期):2024.37(1)
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