Objective To explore the compensatory effect of exercise on brain activation abnormalities caused by sleep disorders.Methods Brain imaging meta-analysis was conducted using activation likelihood estimation(ALE)to investigate brain activation abnormalities caused by sleep disorders and changes in brain activation related to exercise.Results A total of 119 studies were included,and it was found that there was widespread activation in the bilateral frontal areas,hippocampus,superior and middle temporal gyri,and some regions of the thalamus in abnormal brain regions related to sleep disorders and brain regions after exercise intervention.Conclusion Exercise may play an important role in alleviating brain activation abnormalities caused by sleep disorders.