Correlation analysis between serum neurofilament light and peroxiredoxin 1 levels and the neurological and cognitive function of patients with Wilson's disease
Objective To evaluate correlations between levels of neurofilament light(NfL)and peroxiredoxin 1(PRDX1)in the serum of Wilson's disease(WD)patients and their neurological and cognitive function.Methods In total,this study included 120 WD patients who were admitted to our hospital between April 2022 and April 2024.WD patient classification was performed based on analyses of neurological function(Modified Young Scale)and cognitive function(MMSE scales).As normal control subjects,30 healthy volunteers who completed health examinations at our hospital over this same time period were enrolled as normal control group.Serum NfL and PRDX1 levels were detected via ELISA,and Pearson correlation analyses were used to assess correlations between the serum levels of these proteins and WD patient neurological and cognitive function.Results Significantly increased serum NfL and PRDX1 levels were observed in WD patients relative to normal control group(all P＜0.05),and the levels of serum NfL and PRDX1 in the serum of WD patients exhibiting high neurological function scores were significantly higher than those in WD patients exhibiting low neurological function scores(all P＜0.05).Positive correlations were observed between these WD patient neurological function scores and serum levels of both NfL and PRDX1(all P＜0.05).Moreover,WD patients with cognitive impairment exhibited significantly elevated serum NfL and PRDX1 levels as compared to normal control group(all P＜0.05),and the serum levels of NfL and PRDX1 in WD patients with lower cognitive function scores were significantly higher than those with higher cognitive function scores(all P＜0.05).A negative correlation was detected between WD patient cognitive function scores and serum levels of both NfL and PRDX1(all P＜0.05).Conclusion NfL and PRDX1 serum levels are closely related to the severity of neurological and cognitive impairment in WD patients,and they may offer utility as auxiliary biomarkers for the assessment of cognitive and neurological impairment in patients with WD.
Wilson'diseaseneurofilament lightperoxiredoxin 1cognitive function
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