Research progress on the role of microRNA in Alzheimer's disease
Alzheimer's disease(AD)is a common neurodegenerative disease characterized by the accumulation of β-amyloid plaques and neurofibrillary tangles in the brain.MicroRNAs(miRNAs)are a class of small molecule non-coding RNAs that are maturely processed from precursor miRNAs by the action of enzymes such as Dicer.miRNAs play an important role in a variety of biological processes by binding to target mRNAs to regulate gene expression.Studies found that a variety of miRNAs were abnormally expressed in the brain tissues and peripheral body fluids of AD patients,and these miRNAs were involved in AD-related β-amyloid metabolism,synaptic function,neuronal apoptosis,and neuroinflammation.This article reviews the role of miRNA in the pathology of AD,and provides a theoretical basis for its application in the diagnosis and treatment of AD.
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