Objective To investigate the impact of modified electric field patch operation method on scalp adverse reactions in glioblastoma(GBM)patients undergoing tumor treating fields(TTFields).Methods A total of 73 GBM patients who received TTFields from May 2019 to July 2022 in Tangdu Hospital were selected as the study subjects.Among them,36 patients treated with the conventional electric field patch operation method before April 2021 served as the control group,and 37 treated after May 2021 were served as the modified group,using the improved technique involved adhesion and removal in electric field patch,and management in high-temperature environments.The incidence of adverse scalp reactions and compliance of TTFields were compared between the two groups.Results The incidence of scalp pruritus(P=0.024 6),contact dermatitis(P=0.025 3),and skin ulceration(P=0.029 9)in the modified group were significantly lower than those in the control group.Compliance of TTFields was significantly higher in the modified group than in the control group(81.1％vs 52.8％,P=0.010 1).The incidence of adverse scalp reactions varied with seasons,being highest in summer(56.16％)and lowest in winter(8.22％).After adopting the modified electric field patch operation method,the occurrence of adverse scalp reactions in summer(P=0.000 2),autumn(P=0.041 1),and spring(P=0.034 2)was significantly reduced.Conclusion The modified electric field patch operation method can effectively prevent scalp adverse reactions,reduce treatment interruptions,and improve treatment compliance in patients with TTFields.
维普
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