Objective To analyze the prognosis of patients with medulloblastoma at different ages,and to explore the influence of immune cell infiltration on prognosis and the correlation with age,and screen age-related immune regulatory molecules.Methods In the study,cohorts from public database were studied through informatic analysis,Kaplan-meier curves were used for survival analysis,and MCPcounter was used to quantify the absolute abundance of immune cells in different ages.Meanwhile,age-related different expression genes were screened,and the effects of different expression genes on immune cell infiltration were analyzed.Results The survival rate of patients aged 0-3 years was the lowest among all patients in the cohort.The number of CD8+T cells,cytotoxic lymphocytes,neutrophils and B lineage in the tumor microenvironment of infants were significantly lower than other age groups,while the number of tumor-associated fibroblasts,monocyte lineage and endothelial cells were significantly higher than other age groups.The expression of CXCR4 was negatively correlated with the infiltration of effector immune cells and positively correlated with tumor-associated cells,which were closely related to the prognosis of medulloblastoma.Conclusion The poor prognosis of infants medulloblastoma is closely related to the remodeling of tumor microenvironment mediated by CXCR4 expression.
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