Objective To investigate the clinical characteristics and postoperative follow-up of gliosarcoma(GSM).Methods The clinical data of 13 patients with GSM who underwent surgery at the Affiliated Hospital of Guizhou Medical University from August 2012 to July 2020 were retrospectively analyzed,including basic clinical features,preoperative imaging features,and postoperative molecular pathological findings.Follow-up was performed,until the patient died.Results 8 male and 5 female patients with GSM were collected.The average age was 51.69 years old,ranging from 23 to 70 years old.The chief complaints of most patients were dizziness and headache,and the mainly located on the supratentorial region.Preoperative MRI showed that the lesions were mainly lumpy in T1 WI and T2WI.T,enhanced MRI revealed annular enhancement or irregular enhancement.All the pathological diagnosis after operation indicated both glioblastoma components and sarcoma components,and reticulofibers staining was positive,staining by positive cells of glial fibrillary acidic protein,vimentin,S-100 and Olig-2.Postoperative radiotherapy was 3 cases and temozolomide chemotherapy was 8 cases.Postoperative follow-up revealed recurrence in 5 cases,including 3 of primary focus recurrence,1 of extracranial metastasis via cerebrospinal fluid,and 1 of metastasis to medulla oblongata and the fourth ventricle,with 8.47 months of the overall median survival.Conclusions GSM,mainly diagnosed by pathological features,was rare and relapsed easily.Generally,GSM transfers to adjacent brain tissues and metastasized natural anatomical pathways,with poor prognosis.
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