Objective To explore the clinical features,imaging features and treatment of completely cystic spinal cord ependymoma.Methods The clinical data of 1 case of spinal cord ependymoma with complete cystic transformation admitted to Department of Neurosurgery,the Second Affiliated Hospital of Nanchang University in April 2021 were analyzed retrospectively,and the related literature were reviewed.Results Intraoperative findings showed that the tumor was pink and soft with a certain capsule.The tumor was almost completely cystic with dark red fluid.The cyst wall was tumor tissue with a thickness of about 2-3 mm.Postoperative pathological diagnosis was spinal cord ependymoma(WHO Grade Ⅱ).After 6 months of follow-up,no tumor recurrence was found.Conclusions Spinal cord ependymom is often accompanied by cystic changes.Complete cystic changes are rare and the cystic walls are mostly tumor cells.Plain MRI shows low signal on T1 and high signal on T2,while enhanced MRI shows ring enhancement.The clinical manifestations are mostly neurological impairment at corresponding stages.For completely cystic tumors,the key to the treatment is to preserve the integrity of the cyst wall as much as possible and remove the tumor completely,so as to avoid the dissemination and metastasis of tumor cells along with the cyst fluid.