Objective To explore the treatment of endoscopic endonasal pituitary transposition trans-tuber-cinereum approach(EEPTTCA)for resection of the third ventricle craniopharyngioma.Methods The clinical data of a patient underwent third ventricle craniopharyngioma resection by EEPTTCA at the Department of Neurosurgery,Zhongshan Hospital,Fudan University in July 2022 were analyzed retrospectively.The relevant literature were also reviewed.Results EEPTTCA could expose tuber cinereum clearly and trans-tuber-cinereum approach could totally resect the tumor originated from the third ventricle.There were no postoperative complication.No tumor recurrence was observed during six-month follow-up.Conclusions EEPTTCA is an alternative route for this special type of craniopharyngioma.This approach can effectively expose the anterior lesions of the third ventricles from bottom to top,avoiding traction damage to the optic chiasm.