Objective To explore the influencing factors of total resection for petroclival meningiomas.Methods The clinical data of 57 patients with petroclival meningioma who underwent surgery in Wuhan Brain Hospital from January 2011 to December 2021 were analyzed retrospectively.Multivariate logistic regression analysis was used to test the influencing factors of total resection,and the KPS before and after surgery was compared.Results Among 57 patients,35 had complete tumor resection and 22 had incomplete tumor resection,with a total resection rate of 61.40%.Multivariate logistic regression analysis showed that tumor texture,diameter,tumor blood supply and invasion of cavernous sinus were independent influencing factors of total resection of petroclival meningioma(P<0.05).The average preoperative KPS score was 83.51,and the average follow-up KPS score was 87.34.KPS improved significantly in patients with severe brain stem compression(P<0.05).Conclusions Total resection of meningiomas in the petroclival region can reduce recurrence and improve functional prognosis.Tumor texture,size,invasion of the cavernous sinus,compression of the brain stem,abundant blood supply of the tumor surrounded by blood vessels and nerves,and the choice of surgical approaches are important factors affecting total tumor resection.