Correlation between perioperative variability of serum IGF-1 and effect of sympathetic plexus excision of common carotid artery in children with cerebral palsy
Objective To explore the correlation between perioperative variability of serum insulin-like growth factor-1(IGF-1)and the efficacy of carotid peripheral sympathetic network resection in children with cerebral palsy(CP).Methods 179 children with CP who underwent carotid sympathetic plexus excision in the Second Affiliated Hospital of Xinjiang Medical University from January 2019 to December 2022 were selected as study subjects.Clinical data of all children were collected.The children were then followed up for a period of 6 months,and the correlation between IGF-1 variability and outcome was analyzed by counting the outcome at the end of the follow-up.Results By the end of the follow-up on June 30,2023,of the 179 children,61 were evaluated as effective,84 were effective,and 34 were ineffective.So they were divided into improvement group(n=145)and ineffective group(n=34)according to therapeutic effect.Serum IGF-1,Mean,SD,coefficient of variation(CV)of children in the ineffective group were significantly lower than those in the improved group at all time points,and the difference was statistically significant(P＜0.05).IGF-1(CV)(OR=0.059)was an independent protective factor affecting surgical efficacy(P＜0.05).IGF-1(CV)was better than IGF-1(before surgery)and IGF-1(7 days after surgery)in predicting area under curve(AUC)for cerebral palsy children(P＜0.05),and the prediction accuracy of IGF-1(CV)was significantly higher than that of IGF-1(before surgery)and IGF-1(7 days after surgery)(P＜0.05).Conclusion There is a correlation between perioperative IGF-1 variability and the efficacy of carotid sympathetic plexus excision for children with CP.
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