Paroxysmal sympathetic hyperactivity(PSH)syndrome is a common complication after moderate to severe traumatic brain injury(TBI).It is characterized by simultaneous and paroxysmal increase in sympathetic excitability(high fever,elevated blood pressure,increased heart rate,tachypnea,hyperhidrosis)and postural or muscular tension disorders.There are individual differences in the clinical manifestations of PSH,the symptoms are lack of specificity,and it is easy to be confused with sepsis,epilepsy and other diseases at the early stage.At present,the pathogenesis of PSH is not clear,and the diagnosis is mainly through clinical manifestations and exclusion of other diseases.It is usually misdiagnosed and delayed in treatment,and ultimately hinder the rehabilitation process of TBI patients.At present,the treatment of PSH is mainly preventing and controlling symptoms,and there is still no unified and effective management plan,which affects the prognosis of TBI.This article reviews the clinical characteristics,pathogenesis,diagnosis and treatment of PSH after traumatic brain injury in order to provide guidance for the early diagnosis and treatment of PSH.