Glioma is a common malignant tumor within the cranium,presenting significant challenges in treatment and poor prognosis.Consequently,the investigation of the pathogenic mechanisms and therapeutic strategies for glioma represents a current focal point within the field of neuro-oncology.Serine is a critical non-essential amino acid,not only providing essential precursors for the synthesis of intracellular proteins,nucleic acids,and lipids,but also contributing to the maintenance of the redox homeostasis within tumor cells,playing a crucial role in the physiological and pathological processes of cells.In recent years,research has found a close association between serine metabolism and the development of glioma.This review aims to provide an overview of the role of serine in the progression of glioma,its potential mechanisms,and therapeutic.
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